KARINA MARTINEZ MAYORGA

Entidad: Instituto de Química, UNAM

Telefono: 46614

Email: sasu_mx@yahoo.com kmtzm@unam.mx

Url: http://www.iquimica.unam.mx/premiosiq-alias/93-fq/182-investigadoramayorga-alias

Departamento: Fisicoquímica

Línea de trabajo y/o generación del conocimiento: Fisicoquímica

Línea de trabajo y/o generación del conocimiento: Química Teórica y Computacional


Tesis Doctorado

TesisAlumno
MECANISMOS DE REACCION Y BIOGENESIS DE TERPENOS CON POSIBLE ACTIVIDAD SOBRE RECEPTORES OPIOIDES JAVIER ALEJANDRO POSADA SALGADO

Tesis Maestría

TesisAlumno
Selectividad funcional del receptor opioide mu evaluado a través de simulaciones de dinámica molecular y cálculo de la energía libre, promedio 9.71 ANDRES FELIPE MARMOLEJO VALENCIA

Publicaciones:

  • Interaction Fingerprints and Their Applications to Identify Hot Spots
    Marmolejo, Andrés F.,Medina-Franco, José L.,Giulianotti, Marc,Martinez-Mayorga, Karina
    Methods in Molecular Biology 2015, (), , 313 - 324
    doi: 10.1007/978-1-4939-2914-6_20 ·
  • Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays
    Ramos-Molina, Bruno,Lick, Adam N.,Blanco, Elias H.,Posada-Salgado, J. Alejandro,Martinez-Mayorga, Ka
    Biochemical Pharmacology 2015, (96), 2, 107 - 118
    doi: 10.1016/j.bcp.2015.05.008
  • Cruzain inhibitors: efforts made, current leads and a structural outlook of new hits
    Martinez-Mayorga, Karina,Byler, Kendall G.,Ramirez-Hernandez, Ariadna I.,Terrazas-Alvares, Diana E.
    Drug Discovery Today 2015, (20), 7, 890 - 898
    doi: 10.1016/j.drudis.2015.02.004
  • Synthesis, anti-inflammatory activity and modeling studies of cycloartane-type terpenes derivatives isolated from Parthenium argentatum
    Romero, Juan Carlos,Martínez-Vázquez, Adriana,Herrera, Maribel Pineda,Martinez-Mayorga, Karina,Parra
    Bioorganic & Medicinal Chemistry 2014, (22), 24, 6893 - 6898
    doi: 10.1016/j.bmc.2014.10.028
  • The Interplay Between Molecular Modeling and Chemoinformatics to Characterize Protein–Ligand and Protein–Protein Interactions Landscapes for Drug Discovery
    Medina-Franco, José L.,Méndez-Lucio, Oscar,Martinez-Mayorga, Karina
    Advances in Protein Chemistry and Structural Biology 2014, (), , 1 - 37
    doi: 10.1016/bs.apcsb.2014.06.001
  • Balancing novelty with confined chemical space in modern drug discovery
    Medina-Franco, José L,Martinez-Mayorga, Karina,Meurice, Nathalie
    Expert Opinion on Drug Discovery 2014, (9), 2, 151 - 165
    doi: 10.1517/17460441.2014.872624
  • Retinal Ligand Mobility Explains Internal Hydration and Reconciles Active Rhodopsin Structures
    Leioatts, Nicholas,Mertz, Blake,Martínez-Mayorga, Karina,Romo, Tod D.,Pitman, Michael C.,Feller, Sco
    Biochemistry 2014, (53), 2, 376 - 385
    doi: 10.1021/bi4013947
  • Systematic Mining of Generally Recognized as Safe (GRAS) Flavor Chemicals for Bioactive Compounds
    Martinez-Mayorga, Karina,Peppard, Terry L.,López-Vallejo, Fabian,Yongye, Austin B.,Medina-Franco, Jo
    J. Agric. Food Chem. 2013, (61), 31, 7507 - 7514
    doi: 10.1021/jf401019b
  • Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure
    Martinez-Mayorga, Karina,Byler, Kendall G.,Yongye, Austin B.,Giulianotti, Marc A.,Dooley, Colette T.
    European Journal of Medicinal Chemistry 2013, (66), , 114 - 121
    doi: 10.1016/j.ejmech.2013.05.021
  • The role of imidazole in peptide cyclization by transesterification: parallels to the catalytic triads of serine proteases
    Byler, Kendall G.,Li, Yangmei,Houghten, Richard A.,Martinez-Mayorga, Karina
    Organic & Biomolecular Chemistry 2013, (11), 18, 2979 -
    doi: 10.1039/c3ob27464k
  • Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study
    Yongye, Austin B.,Vivoli, Mirella,Lindberg, Iris,Appel, Jon R.,Houghten, Richard A.,Martinez-Mayorga
    PLoS ONE 2013, (8), 2, e56957 -
    doi: 10.1371/journal.pone.0056957
  • Chemoinformatic Analysis of GRAS (Generally Recognized as Safe) Flavor Chemicals and Natural Products
    Medina-Franco, José L.,Martínez-Mayorga, Karina,Peppard, Terry L.,Del Rio, Alberto
    PLoS ONE 2012, (7), 11, e50798 -
    doi: 10.1371/journal.pone.0050798
  • Prediction of the experimental regioselectivity of C 60 fullerene bis-adducts
    Chaker, Leila,Yongye, Austin B.,Nefzi, Adel,Martínez-Mayorga, Karina
    Journal of Physical Organic Chemistry 2012, (25), 11, 894 - 901
    doi: 10.1002/poc.2943
  • Corrigendum to ‘Furin inhibitors: Importance of the positive formal charge and beyond’ [Bioorg. Med. Chem. 20 (2012) 4462–4471]
    López-Vallejo, Fabian,Martínez-Mayorga, Karina
    Bioorganic & Medicinal Chemistry 2012, (20), 20, 6195 - 6197
    doi: 10.1016/j.bmc.2012.08.027
  • Molecular Recognition of the Thomsen-Friedenreich Antigen–Threonine Conjugate by Adhesion/Growth Regulatory Galectin-3: Nuclear Magnetic Resonance Studies and Molecular Dynamics Simulations
    Yongye, Austin B.,Calle, Luis,Ardá, Ana,Jiménez-Barbero, Jesús,André, Sabine,Gabius, Hans-Joachim,Ma
    Biochemistry 2012, (51), 37, 7278 - 7289
    doi: 10.1021/bi300761s
  • Furin inhibitors: Importance of the positive formal charge and beyond
    López-Vallejo, Fabian,Martínez-Mayorga, Karina
    Bioorganic & Medicinal Chemistry 2012, (20), 14, 4462 - 4471
    doi: 10.1016/j.bmc.2012.05.029
  • Recognizing Pitfalls in Virtual Screening: A Critical Review
    Scior, Thomas,Bender, Andreas,Tresadern, Gary,Medina-Franco, José L.,Martínez-Mayorga, Karina,Langer
    Journal of Chemical Information and Modeling 2012, (52), 4, 867 - 881
    doi: 10.1021/ci200528d
  • Identification of benzoylisoquinolines as potential anti-Chagas agents
    Byler, Kendall G.,Brito-Arias, Marco,Marquez-Navarro, Adrian,Nogueda-Torres, Benjamin,Torres-Bustill
    Bioorganic & Medicinal Chemistry 2012, (20), 8, 2587 - 2594
    doi: 10.1016/j.bmc.2012.02.046
  • Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine Derivatives
    Vivoli, M.,Caulfield, T. R.,Martinez-Mayorga, K.,Johnson, A. T.,Jiao, G.-S.,Lindberg, I.
    Molecular Pharmacology 2011, (81), 3, 440 - 454
    doi: 10.1124/mol.111.077040
  • Computational methods for the discovery of mood disorder therapies
    López-Vallejo, Fabian,Peppard, Terry L,Medina-Franco, José L,Martínez-Mayorga, Karina
    Expert Opinion on Drug Discovery 2011, (6), 12, 1227 - 1245
    doi: 10.1517/17460441.2011.637106
  • Multitarget Structure–Activity Relationships Characterized by Activity-Difference Maps and Consensus Similarity Measure
    Medina-Franco, José L.,Yongye, Austin B.,Pérez-Villanueva, Jaime,Houghten, Richard A.,Martínez-Ma
    Journal of Chemical Information and Modeling 2011, (51), 9, 2427 - 2439
    doi: 10.1021/ci200281v
  • Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery
    Lopez-Vallejo, Fabian,Caulfield, Thomas,Martinez-Mayorga, Karina,A. Giulianotti, Marc,Nefzi, Adel,A.
    Combinatorial Chemistry & High Throughput Screening 2011, (14), 6, 475 - 487
    doi: 10.2174/138620711795767866
  • Consensus Models of Activity Landscapes with Multiple Chemical, Conformer, and Property Representations
    Yongye, Austin B.,Byler, Kendall,Santos, Radleigh,Martínez-Mayorga, Karina,Maggiora, Gerald M.,Medi
    Journal of Chemical Information and Modeling 2011, (51), 6, 1259 - 1270
    doi: 10.1021/ci200081k
  • Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation
    Struts, Andrey V,Salgado, Gilmar F J,Martínez-Mayorga, Karina,Brown, Michael F
    Nat Struct Mol Biol 2011, (18), 3, 392 - 394
    doi: 10.1038/nsmb.1982
  • Integrating computational and mixture-based screening of combinatorial libraries
    Yongye, Austin B.,Pinilla, Clemencia,Medina-Franco, Jose L.,Giulianotti, Marc A.,Dooley, Colette T.,
    Journal of Molecular Modeling 2010, (17), 6, 1473 - 1482
    doi: 10.1007/s00894-010-0850-1
  • Dynamic clustering threshold reduces conformer ensemble size while maintaining a biologically relevant ensemble
    Yongye, Austin B.,Bender, Andreas,Martínez-Mayorga, Karina
    Journal of Computer-Aided Molecular Design 2010, (24), 8, 675 - 686
    doi: 10.1007/s10822-010-9365-1
  • Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies
    Yongye, Austin B.,Giulianotti, Marc A.,Nefzi, Adel,Houghten, Richard A.,Martínez-Mayorga, Karina
    Journal of Computer-Aided Molecular Design 2010, (24), 3, 225 - 235
    doi: 10.1007/s10822-010-9328-6
  • Dynamics of Retinal Studied by 2H NMR Relaxation Underlie Multiscale Conformational Changes in Rhodopsin Activation
    Struts, Andrey V.,Salgado, Gilmar F.J.,Martínez-Mayorga, Karina,Brown, Michael F.
    Biophysical Journal 2010, (98), 3, 175a -
    doi: 10.1016/j.bpj.2009.12.4218
  • Protonation Switches in GPCR Activation: Physiologically Significant Rhodopsin Photointermediates
    Lewis, James W.,Martinez-Mayorga, Karina,Szundi, Istvan,Kliger, David S.,Brown, Michael F.
    Biophysical Journal 2010, (98), 3, 288a - 289a
    doi: 10.1016/j.bpj.2009.12.1573

Patentes: